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How the immune system fails as cancer arises

by Medical Xpress
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Credit: Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2406748121

Cancer has been described as “a wound that does not heal,” implying that the immune system is unable to wipe out invading tumor cells. A new discovery confirms that a key molecule can reprogram immune cells that normally protect against infection and cancer, turning them into bad guys that promote cancer growth.

Studying the behavior of these “pro-tumor” immune cells is important because they could be targets for therapies that block their harmful activity, said Minsoo Kim, Ph.D., corresponding author of the study and a research leader at the Wilmot Cancer Institute.

The Proceedings of the National Academy of Sciences published the discovery.

Kim led a team of scientists investigating the dynamic interactions that occur between cells in the tumor environment, and the underlying factors that cause the harmful transformation of immune cells from good to bad.

They found that PAF (platelet-activating factor) is the key molecule that controls the destiny of the immune cells. PAF not only recruits -promoting cells, but it also suppresses the immune system’s ability to fight back. In addition, they found that multiple cancers rely on the same PAF signals.







Neutrophils isolated from the spleen of naïve GFP-expressing mice (GFP) or tumor-bearing Catchup mice (red) were plated with KCKO tumoroids. Both GFP- and tdTomato-expressing neutrophils migrate to the tumoroid and stay motile. Time is marked as hr:min. Bar = 50 μm. Credit: Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2406748121

“This is what could be most significant,” said Kim, a Dean’s professor of Microbiology and Immunology at the University of Rochester Medical Center. “Because if we find a treatment that could interfere with PAF, it could potentially apply to many types of cancer.”

Much of the team’s work focused on pancreatic cancer cells. It is one of the most deadly cancers, with a five-year survival rate of about 12%, and is notoriously hard to treat because pancreatic tumors are surrounded by a toxic stew of proteins and other tissues that protect the cancer from the ‘s natural role to attack invaders.

They also studied breast, ovarian, colorectal, and lung cancer cells, using advanced 3D imaging technology to watch the behavior of as they swarmed to the cancerous region.

More information:
Ankit Dahal et al, Platelet-activating factor (PAF) promotes immunosuppressive neutrophil differentiation within tumors, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2406748121

Citation:
How the immune system fails as cancer arises (2024, September 12)
retrieved 12 September 2024
from https://medicalxpress.com/news/2024-09-immune-cancer.html

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