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Exploring the role of the gut barrier in colorectal cancer treatment

by Medical Xpress
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Graphical abstract. Credit: 2024 Hajjar et al.

A new review titled “The gut barrier as a gatekeeper in colorectal cancer treatment” has been published in Oncotarget.

Colorectal cancer (CRC) is highly prevalent and a major cause of cancer-related deaths worldwide. The primary curative treatment for CRC is surgical resection of the affected bowel segment. However, often include a weakened gut barrier and the dissemination of bacterial proinflammatory lipopolysaccharides.

Researchers discuss how gut microbiota and microbial metabolites regulate basal inflammation levels in the gut and the healing process of the bowel after surgery.

“We and others have shown in the last few years that influences the healing process of the bowel and the restoration of the gut barrier after surgery,” explain the researchers.






They further elaborate on the restoration of gut barrier function in CRC patients and how this potentially impacts the dissemination and implantation of CRC cells in extracolonic tissues, thereby contributing to worse survival outcomes after surgery.

“Based on our recent work, we believe that weakened gut barrier function, namely due to poor healing after , leads to persistent systemic low-grade inflammation and a higher risk of local and systemic cancer recurrence,” they conclude.

More information:
Roy Hajjar et al, The gut barrier as a gatekeeper in colorectal cancer treatment, Oncotarget (2024). DOI: 10.18632/oncotarget.28634

Provided by
Impact Journals LLC

Citation:
Exploring the role of the gut barrier in colorectal cancer treatment (2024, August 19)
retrieved 19 August 2024
from https://medicalxpress.com/news/2024-08-exploring-role-gut-barrier-colorectal.html

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