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Research confirms circZFR is a promising biomarker for colorectal cancer diagnosis and prognosis

by Medical Xpress
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The level of circZFR is associated with CRC stage and survival, and circZFR promotes CRC growth and metastasis in vivo. Credit: Science China Press

In a study published in the journal Science China Life Sciences, a research team identified circZFR using circRNA microarray and competing endogenous RNA (ceRNA) microarray, and they confirmed that circZFR is a promising biomarker for colorectal cancer (CRC) diagnosis and prognosis.

Currently, the morbidity and mortality of CRC remain high due to the lack of early symptoms and effective early screening technology. Metastasis and recurrence remain the most common causes of death related to CRC. Therefore, it is crucial to find novel biomarkers for CRC and prognosis, as well as unravel their mechanisms of action.

The team studied the function of circZFR, as well as the upstream and downstream events that promote CRC progression. Highly expressed circZFR promotes the proliferation and migration of CRC cells directly or via exosomes. In mouse models, circZFR stimulates , and lung and liver .

Mechanistically, ESRP1 in CRC cells may enhance the production of circZFR. The oncogenic protein BCLAF1 binds to circZFR, preventing the ubiquitinated degradation of BCLAF1. In addition, circZFR sponges miR-3127-5p to boost RTKN2 expression. These findings support the use of circZFR as a potential biomarker for CRC diagnosis and a desirable target for future treatment.

  • The mechanism of a novel circular RNA circZFR that promotes colorectal cancer progression
    circZFR promotes CRC progression via stabilizing BCLAF1 and regulating the miR-3127-5p/RTKN2 axis. Credit: Science China Press
  • The mechanism of a novel circular RNA circZFR that promotes colorectal cancer progression
    TCP1-CD-QDs loaded with si-circZFR target CRC tissues and promote CRC growth. Credit: Science China Press

The study further shows that the TCP1-CD-QDs nanocarrier is able to carry and deliver circZFR siRNA (si-circZFR) to the vasculature of CRC tissues, effectively inhibiting tumor growth.

“The unique looping structure of circRNAs renders them extremely stable, implying that these molecules have a strong potential for early screening, diagnosis, and prognosis. Our study on circZFR will provide help for researchers in this field to explore more novel functional circRNAs,” Zhangfa Song—the senior author of the study—noted.

More information:
Jiaxin Chen et al, CircZFR promotes colorectal cancer progression via stabilizing BCLAF1 and regulating the miR-3127-5p/RTKN2 axis, Science China Life Sciences (2024). DOI: 10.1007/s11427-023-2514-y

Citation:
Research confirms circZFR is a promising biomarker for colorectal cancer diagnosis and prognosis (2024, July 5)
retrieved 5 July 2024
from https://medicalxpress.com/news/2024-07-circzfr-biomarker-colorectal-cancer-diagnosis.html

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