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Null causal relationship between inflammatory bowel disease and lipid profile

by Medical Xpress
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Apo A, apolipoprotein A; Apo B, apolipoprotein B; CD, Crohn’s disease; HDL-C, high-density lipoprotein cholesterol; IBD, inflammatory bowel disease; IVW, inverse-variance weighted; LDL-C, low-density lipoprotein cholesterol; Lp(a), lipoprotein (a); TC, total cholesterol; TG, triglycerides; UC, ulcerative colitis. Credit: Xiaoli Pang, Huizhong Yang, Mingyu Li, Mayte Suarez-Farinas, Suyan Tian

A new study has illuminated the connection between inflammatory bowel disease (IBD) and lipid profile. IBD is a chronic condition that causes inflammation in the intestines. Abnormal lipid factor levels such as cholesterol in IBD patients have been observed in previous studies, but whether this association is causal remained unclear.

The research is published in the journal eGastroenterology.

This study employed Mendelian randomization (MR) to investigate the potential causal link between lipid profile and IBD. The results revealed no significant causal relationship between seven lipid factors and the risk of developing IBD. Consistent results were obtained for two subtypes of IBD, Crohn’s disease and .

The authors acknowledge that prior studies have shown discrepancies in lipid levels among IBD patients. For example, some reports indicate lower levels in individuals with IBD compared to healthy controls, while others find no substantial differences. These inconsistencies underscore the limitations of conventional observational studies, which are prone to confounding factors and reverse causation. In contrast, MR can overcome these limitations.

This study provides valuable insights into the complex interplay between IBD and lipid profile. The findings suggest that regulating lipid levels may not directly influence the risk of IBD. However, further research is necessary to fully understand the relationship between lipids and IBD.

Null causal relationship between inflammatory bowel disease and lipid profile
(A) For the discovery set; and (B) for the validation set. Apo A, apolipoprotein A; Apo B, apolipoprotein B; HDL, high-density lipoprotein; LDL, low-density lipoprotein; Lp(a), lipoprotein (a); TC, total cholesterol; TG, triglyceride. Credit: Xiaoli Pang, Huizhong Yang, Mingyu Li, Mayte Suarez-Farinas, Suyan Tian

More information:
Xiaoli Pang et al, To explore the causal association between the serum lipid profile and inflammatory bowel disease using bidirectional Mendelian randomisation analysis, eGastroenterology (2024). DOI: 10.1136/egastro-2023-100034

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First Hospital of Jilin University

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Null causal relationship between inflammatory bowel disease and lipid profile (2024, June 27)
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